SYNENTEC provides in the field of automated imaging systems the latest standard in image acquisition, device controlling and image- and data analysis software. And the available data batch-processing solutions provide highest claims in plate throughput.
What started as YT-Software has diversified into a whole ecosystem of possibilities to optimize throughput, reliability and precision as well as customization.
The YT-Software ecosystem consists of separate building blocks that can be used to generate processes tailored for our customers’ requirements.
All systems are cross-compatible to perform the exact task in the exact right time in lightning speed and with highest accuracy.
Get an overview of the wide range of YT-Software ecosystem. >>>
The YT-software® offers a complete tool: starting from experimental set-up and automatic high throughput image acquisition over precise image analysis up towards the storage, handling and processing of data for documentation and presentation purposes. And the high-resolution, stored images mean your results can be tracked over years to come!
Data generation in CELLAVISTA® and NYONE® is conducted using one of SYNENTEC’s 65 proprietary image processing algorithms that can be used for a variety of applications. The high quality images are analyzed for specific properties, e.g. cells or cell features and the results are visualized using overlays in YT-software®.
The software also evaluates the results generated in a per well manner to readily display the data obtained in a comprehensive form. These well based results can be exported in a machine readable format to be incorporated in well based decision making for example in binding studies, response analyses like cytotoxicity or hitpicking in a CLD or Drug Discovery setting. All parameters for a specific assay, incl. imaging, image processing and export variables can be stored in so called templates, which are enabling human free operation.
Supports all common Applications needed to run your R&D Processes in high Throughput
Cell Line Development (e.g. Single Cell Cloning, CRISPR/Cas9 Tracking, Transfection Efficiency, Cell Viability Monitoring, PAIA Protein Titer Measurements, PAIA Glycosylation Measurements, Fluorescent Activated Single Cell Cloning (FASCC))
Cancer Research and Drug Discovery (e.g. Imaging of 3D Spheroids, Toxicity Testing, IC50 studies, Cell Expansion Tracking, Apoptosis Monitoring, Nucleus Characterization)
Stem Cell Research (e.g. iPS Colony Count, Fluorescent Pluripotency Studies, Validation of Proliferation and Cell Migration, Cell Differentiation Analysis, Recombinant Lectin Probes)
Immunology (e.g B-Cell and T-Cell Studies, Cytotoxic T-Lymphocyte Testing, Evaluation of Helper T-Cells and Subsets, Performing Cell Death Studies)
A user-friendly software interface will give you the choice of either using a predefined set-up from a list of established assays or to define your own work flow protocol and store this into a customized template.
Both imaging systems run on the same software platform which makes it easy to transfer your process in case of upgrading from NYONE® for higher throughput of CELLAVISTA®.
Performing automated high-quality image acquisition in parallel with accurate, reliable image analysis
Automated, customizable data and image export function for report creation, documentation and regulatory approval
Supporting automation interfaces
Available data batch-processing solutions for highest claims in plate throughput
Further software licenses in combination with an imaging system independent evaluation mode of the software reduces workstation blocking during data examination
Batch Processing Server
High performance server specifically designed for SYNENTEC`s image processing algorithm and image/data exports
Processing data using Batch Processing Server
Enables highest plate throughput and automated data handling
Automatic, sequential, and complete processing of all data contained in one or more input files
Performs completely independent (e.g. over night)
API enabling external access for third party software, e.g. automation scheduling software integration
Massive parallel data processing for multiple experiments and runs
Changes of image processing algorithm
Automatic export of data and images
Export capabilities – Save It, Sort It, Show It, Store It!
Image Processing Settings
High Content Object Data
Clone Galery for SCC
Plate Overview & Plate Heat Map
Well Channels & Well Overlay
All taken Raw-Images as ZIP-container
Add Brightness, Contrast and Normalization Settings to Image
Data Handling – No Longer A Confusing Battle
The ‘Results’ tab is used to have the data, created by the image processing, displayed as numbers in a spreadsheet format consisting of columns and rows. The columns can be clicked and dragged to rearrange them in a way that fits the users' needs.
The Heat map displays the selected data in a color-coded way: low values will appear in blue, high values in red. The heat map is displayed in the respective plate format and can be used for navigation as the navigator tab.
The Time Chart option is used to display data from different measurements of the same experiment. It displays all measurement data in the corresponding plate format as line charts. With a dropdown menu the user can select the property of displayed data. The curves of selected wells also will also be displayed in the ‘Details’ section.
The scatterplot is used to investigate correlations between different sample parameters, e.g. cell diameter vs. cell fluorescence intensity to visualize different populations of cells. To selectively analyze certain objects with properties of interest, one can use the gating function within the scatterplot.
The ‘Histogram’ can be used to display the distribution of the selected metric property, e.g. the mean intensity of the found objects within the selected wells. The median of the selected dataset is marked with a red bar in the histogram.
Our fast and precise image analysis software allows online visualization of image processing parameter modifications of the taken images.