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A Deleted Deletion Site in a New Vector Strain and Exceptional Genomic Stability of Plaque-Purified Modified Vaccinia Ankara (MVA).

Jordan I1, Horn D2, Thiele K2,3  et al.

1+2ProBioGen AG, Herbert-Bayer-Straße 8, 13086, Berlin, Germany.

3Sartorius Stedim Cellca GmbH, Erwin-Rentschler-Str 21, 88471, Laupheim, Germany.


Modified vaccinia Ankara (MVA); MVA-CR19; CR.pIX; Suspension cell line; Vaccine production; Genome stability



Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops.

Czechowska K et al.1

1Altmattstrasse 1B, 6418 Rothenthurm, Switzerland.

Participating institutions e.g.: 

Center for Biologics Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, MD;  GlaxoSmithKline, Stevenage, UK;  Terry Fox Laboratory-BC Cancer, Canada;  Novartis Pharma AG, Basel, Switzerland;  Schwiete-Laboratory Microbiota and Inflammation, German Rheumatism Research Centre Berlin (DRFZ), a Leibniz Institute, Germany;  MedImmune, an AstraZeneca Company, Gaithersburg, MD;  Biogen, Acute Neurology, Cambridge, MA;  Novo Nordisk Center for Stem Cell Biology; Copenhagen, Denmark; Cardiff University, UK;  Memorial Sloan Kettering Cancer Center, NY;  Genentech, San Francisco, CA;  Bristol-Myers Squibb, Princeton, NJ;  University of Turku and Åbo Akademi University, Finland;  Max Planck Institute for Biology of Ageing, Germany;  Eurofins Pharma Bioanalysis Services UK Ltd, UK;  University of South Alabama, Mobile, AL;  BD Biosciences, California; University of Cambridge, UK;  Helmholtz Center for Environmental Research (UFZ), Leipzig, Germany;  King's College London, UK;  The University of Tokyo;  Dana-Faber Cancer Institute, Boston, MA;  National Institute of Health (NIH), MD;  Weizmann Institute of Science, Israel;  Fred Hutchinson Cancer Research Center, Seattle, WA;  TTP plc, UK;  TU München, Germany;  Amerimmune, Fairfax, VA; University of São Paulo, Brazil;  VIB Center for Inflammation Research, Belgium; The University of Sydney and Centenary Institute, Australia;  Harvard Medical School, Boston, MA;  Roswell Park Comprehensive Cancer Center, NY;  Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.


Cytometry; Quality Assurance; Reproducibility; FDA; EMA; NIST; Assurance of Clonality; Single Cells; Monoclonality



Gene Editing in Primary Cells of Cattle and Pig.

Vochozkova P1 et al.

1Institute for Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany.


CRISPR/Cas; Primary cells; Single cell clones; gRNA



Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5.

Kleemann M1,2 et al.

1Institute of Applied Biotechnology, University of Applied Sciences Biberach, Germany.

2Faculty of Medicine, University of Ulm, Germany.


Cancer; MicroRNA; RAF1; Signalling pathways; Targets; Confluence

DOI: 10.1007/s00018-018-2958-x


Leveraging Mathematical Modeling to Quantify Pharmacokinetic and Pharmacodynamic Pathways: Equivalent Dose Metric.

McKenna MT1,2 et al.

1Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States.


Breast Cancer; Doxorubicin; Mathematical Modeling; Pharmacodynamics; Pharmacokinetic Modeling; Treatment Response




A single-step FACS sorting strategy in conjunction with fluorescent vital dye imaging efficiently assures clonality of biopharmaceutical production cell lines.

Fieder J1, Schulz P2, Gorr I1, Bradl H2, Wenger T3.

1Early Stage Bioprocess Development, Boehringer Ingelheim GmbH & Co. KG, Biberach, Germany.


Biopharmaceutical production cell line; Clonality; FACS; imaging; SCC; Calcein; FASCC



Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts.

Makita Y1, Teratani M1, Murata S1, Hoashi Y1, Matsumoto S1, Kawamata Y1.

1Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan.


Erlotinib; Kinetochore-associated Protein 2; Lipid Nanoparticle; Lung Cancer; Patient-derived Tumor Xenograft; Short Interfering RNA; Three-dimensional Culture; 3D



Impact of nanoparticle surface functionalization on the protein corona and cellular adhesion, uptake and transport.

Ashraf Abdelkhaliq,1,2,3 Meike van der Zande,1 Ans Punt,1 Richard Helsdingen,1 Sjef Boeren,4 Jacques J. M. Vervoort,4 Ivonne M. C. M. Rietjens,2 and Hans Bouwmeester

1RIKILT-Wageningen Research, P.O. Box 230, 6700 AE Wageningen, The Netherlands

KEYWORDS: Nanoparticles; High throughput screening; Cellular adhesion and uptake; Label-free LC–MS/MS; Quantitative proteomics




A single-step FACS sorting strategy in conjunction with fluorescent vital dye imaging efficiently assures clonality of biopharmaceutical production cell lines.

Fieder J1 et al.

1Early Stage Bioprocess Development, Boehringer Ingelheim GmbH & Co. KG, Biberach, Germany.


Biopharmaceutical production cell line; Clonality; FACS; imaging, SCC; FASCC



Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib.

Woo K1, Stewart SG2, Kong GS2, Finch-Edmondson ML2, Dwyer BJ3, Yeung SY2, Abraham LJ2, Kampmann SS2, Diepeveen LA3, Passman AM2, Elsegood CL4, Tirnitz-Parker JE5, Callus BA6, Olynyk JK7, Yeoh GC8.

1The Centre for Medical Research, The Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.


Analogues; Apoptosis; Lenalidomide; Liver cancer; Mitosis; Progenitor cells; Sorafenib; Thalidomide



Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies.

Wirtz ED1, Hoshino D2, Maldonado AT3, Tyson DR3, Weaver AM3.

1Department of Otolaryngology-Head and Neck Surgery, Tripler Army Medical Center, Honolulu, Hawaii.

2Kanagawa Cancer Center, Division of Cancer Cell Research, Yokohama, Kanagawa, Japan.

3Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee.


Cancer; Tumor; Head and Neck squamous cell carcinoma (HNSCC); PIK3CA mutation; IC50; Oncogenes; Cell Viability;
Calcein dye, Hoechst stain, Propidium iodide



Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation.

Ding Z1 et al.

1Stanford, Department of Radiology; Stanford University School of Medicine, Stanford, CA 94305.


Neuroscience; Apoptosis (Annexin V); Neuroinflammation; Neurodegenerative diseases; Pathogenic microglia; Ganciclovir (GCV); Proliferation; Experimental autoimmune encephalomyelitis (EAE); Multiple sclerosis (MS); Central nervous system (CNS) 



Deriving dopaminergic neurons for clinical use. A practical approach.

Gonzalez R1 et al.

1International Stem Cell Corporation, 5950 Priestly Drive, Carlsbad, CA 92008, USA.


Neural stem cells (NSCs); Parkinson’s disease (PD); Substantia nigra (SN); Human pluripotent stem cells (hPSCs); Blood brain barrier; NB medium (NeuroBasal medium); Measuring neurite density



Application of MultiStem(®) Allogeneic Cells for Immunomodulatory Therapy: Clinical Progress and Pre-Clinical Challenges in Prophylaxis for Graft Versus Host Disease.

Vaes B1 et al.

1ReGenesys BVBA Heverlee, Belgium.


GvHD prophylaxis; MultiStem cells; adherent stem cells; bioreactor; regenerative medicine; Cell morphology measurement



The complete automation of cell culture: improvements for high-throughput and high-content screening.

Jain S1 et al.

1VUMC-Clinical Genetics, Amsterdam, the Netherlands.


Automation; Robotics; Cell-based assays, CNS and PNS diseases, Genomics, High-content screening (HCS); HighThroughput (HT)


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