Hardware

IMAGING SYSTEMS AND AUTOMATION SOLUTIONS

By developing and providing fluorescence and brightfield imaging systems and applications, SYNENTEC introduces the most versatile cell imaging systems on the market and also offers proprietary automation solutions such as plate handlers and automated assay incubators, as well as ready-to-use assay kits. Leading the way are the various software- and image analysis packages, which can be expanded according to customer needs.

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CELLAVISTA Scientific & 4K

Ultrahigh-throughput imaging system that non-invasively measures brightfield and fluorescence assays in multi-well plates, chamber slides or RoboFlasks for an extremely broad range of cellular applications in CLD, cellular research and drug discovery.

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NYONE Scientific & 4K

This fully automated cell imager is characterized by its mechanical robustness, optical quality and functionality balanced features in a way that you will soon recognize that NYONE® is a reliable member of your team.

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myrImager Tissue Platform

A video-optical high-throughput imaging platform developed in parallel with the myrPlates to provide drug screening e.g. during the development of new medicines (IND) related to ICH.

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SYBOT X-1000 & CYTOMAT

SYNENTEC offers various peripheral products and robotics for automation to extend functionality and to improve laboratory processes as well as increase throughput and walk away time.

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RESOLUTION MATTERS

Get an idea of the 4k resolution

Explore HCS image analysis capabilities

High content screening using 4K resolution

This image of A549 cells impressively demonstrates the capabilities of SYNENTEC's CELLAVISTA 4K imager. The actin filaments can be recognized with impressive high definition.

COMPARE TECHNICAL SPECIFICATIONS

	CELLAVISTA^® 4K HighEnd¹	NYONE^® 4K HighEnd¹	CELLAVISTA^® 4 Scientific	NYONE^® Scientific	myrImager
Throughput	250² plates / day	100² plates / day	250² plates / day	150² plates / day	48 samples simultaneously (during desired observation period)
Objective capacity	4	3	4	3	1
Selectable Resolutions¹	3.3 µm @ 2x optional 1.3 µm @ 4x 0.9 µm @ 10x 0.53 µm @ 20x 0.35 µm @ 40x	1.3 µm @ 4x 0.9 µm @ 10x 0.53 µm @ 20x	6.5 µm @ 2x optional 3.25 µm @ 4x 1.3 µm @ 10x 0.65 µm @ 20x 0.33 µm @ 40x	6.5 µm @ 2x optional 3.25 µm @ 4x 1.3 µm @ 10x 0.65 µm @ 20x 0.33 µm @ 40x optional	0.086x magnification
Automated whole well/whole plate imaging	✓	✓	✓	✓	whole plate one shot
Sample types	SBS plate format (6-384 wells), culture dishes and microscope slides	SBS plate format (6-384 wells), culture dishes and microscope slides	SBS plate format (6-384 wells), culture dishes and microscope slides	SBS plate format (6-384 wells), culture dishes and microscope slides	myrPlates
Camera	8 bit progressive scan CMOS	8 bit progressive scan CMOS	16 bit sCMOS	16 bit sCMOS	8 bit progressive scan CMOS
Pixel density	5440x 5440 29.6 MPx	4496 x 4496 20.2 MPx	2048 x 2048 4.19 MPx	2048 x 2048 4.19 MPx	3088 x 2064 6.4 MPx
Quantum efficiency (relevant to detect weak fluorescence)	~57 %	~66 %	> 80 %	~80 %	80 %
Light source	High performance long-life LED	High performance long-life LED	High performance long-life LED	High performance long-life LED	Long-life LED
Illumination / Fluorescence¹	Brightfield and 6 fluorescence excitation/emission channels	Brightfield and 4 fluorescence excitation sources, up to 5 fluorescence emission filters	Brightfield and 6 fluorescence excitation/emission channels	Brightfield and 4 fluorescence excitation sources, up to 5 fluorescence emission filters	Long-life LED
Temp.-control	Possible³	×	Possible³	×	24/7 incubator integration
Image acquisition- & device controlling software⁴	YT-SOFTWARE®⁴	YT-SOFTWARE®⁴	YT-SOFTWARE®⁴	YT-SOFTWARE®⁴	YT-myrImage
Automation-ready set up	✓	✓	✓	×	N.A.
Software-interface for automation	✓	✓	✓	✓	N.A.
Batch processing interface	✓	✓	✓	✓	N.A.
External barcode-reader	Optional	Optional	Optional	Optional	Optional

¹ Different system configurations like e.g. basic systems with brightfield only or customized filter and objective lenses set-ups are available.
² Throughput per day depends on experiment configurations (e.g. exposure time, plate type, focus options, # of imaging channels…).
³ CELLAVISTA® can be equipped with the ibidi® heating and incubation system (other systems not tested). Due to pH-shift and consequent cell stress a heating option only is not recommended.
⁴ YT-SOFTWARE® includes the same image analysis tools for both CELLAVISTA® and NYONE®. Differences in usable applications arise only due to different hardware configurations (e.g. different illuminations or camera chips).
⁵ Hardware automation-package available.

Discover all advantages

HIGH CONTENT IMAGING & AUTOMATION

Automation Solutions

Example assay setup

We offer innovative methods and technologies to help you achieve your R&D goals. Our automated cell imagers provide the highest image quality of any cell imaging system on the market, and combined with cutting edge software suites and laboratory automation solutions, ensure the most effective support in your field of application. Some typical examples:

Cell Line Development (e.g. Single Cell Cloning, Proof of Monoclonality, CRISPR/Cas9 Tracking, Transfection Efficiency, Cell Viability Monitoring, PAIA Protein Titer Measurements, PAIA Glycosylation Measurements, Fluorescent Activated Single Cell Cloning (FASCC))
Cancer Research and Drug Discovery (e.g. Imaging of 3D Spheroids, Toxicity Testing, IC50 studies, Cell Expansion Tracking, Apoptosis Monitoring, Nucleus Characterization, Wound Healing & Migration Assay, yH2AX-DNA-Damage, Cell Cycle & Mitosis)
Stem Cell Research (e.g. iPS Colony Count, Fluorescent Pluripotency Studies, Validation of Proliferation and Cell Migration, Cell Differentiation Analysis, Recombinant Lectin Probes, Cornea Cell Count, siRNA Detection, iPS-Cell-Marker Characterization, 3D canractile tissue with the myrImager and the myrPlates)
Immunology (e.g B-Cell and T-Cell Studies, Cytotoxic T-Lymphocyte Testing, Evaluation of Helper T-Cells and Subsets, Performing Cell Death Studies)
Vaccine Research (e.g. Focus Forming Assay (FFA) for Virus Titer Quantification, Immunofluorescence Foci Assay (IFA) for Viral Infectivity, Viral Plaque Assay, Viral Pathogenesis with Quantifying Morphological Changes, Transduction Efficiency with Fluorescence Coupled Gene Expression, Cytopathic Effect Quantification (Viral CPE))

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We know that time is an increasingly scarce resource, even in the lab. That's why we've thought your problem through and have everything ready for a complete one-handed solution.

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