High throughput cell & tissue imaging

Automated high throughput imaging cell microscop.

CELLAVISTA 4

CELLAVISTA® 4 is a fully automated cell imager designed for the characterization of cells as an integral step of your research, development and production process. The CELLAVISTA® 4 imaging system support state-of-the-art automation and can be easily linked with Plate Stackers, Cell printers, Incubators, Liquid Handlers & Clone Pickers.

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NYONE

Due to the fact that many labs run their application in medium throughput, NYONE® is the perfect choice to save money and bench space. This fully automated cell imager is characterized by its mechanical robustness, optical quality and functionality balanced features in a way that you will soon recognize that NYONE® is a reliable member of your team.

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myrImager

The myrImager is a video-optical high-throughput imaging platform developed in parallel with the myrPlates.

It works in combination with the myriamed 48-well 3D cell/tissue culture plates to provide a comprehensive imaging solution for artificial tissue models in research and drug screening e.g. during the development of new medicines (IND) related to ICH.

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RESOLUTION MATTERS

Get an idea of the 4k resolution

Explore HCS image analysis capabilities

High content screening using 4K resolution

This image of A549 cells impressively demonstrates the capabilities of SYNENTEC's CELLAVISTA 4K imager. The actin filaments can be recognized with impressive high definition.

COMPARE TECHNICAL SPECIFICATIONS

	CELLAVISTA^® 4K HighEnd¹	NYONE^® 4K HighEnd¹	CELLAVISTA^® 4 Scientific	NYONE^® Scientific	myrImager
Throughput	250² plates / day	100² plates / day	250² plates / day	150² plates / day	48 samples simultaneously (during desired observation period)
Objective capacity	4	3	4	3	1
Selectable Resolutions¹	3.3 µm @ 2x optional 1.3 µm @ 4x 0.9 µm @ 10x 0.53 µm @ 20x 0.35 µm @ 40x	1.3 µm @ 4x 0.9 µm @ 10x 0.53 µm @ 20x	6.5 µm @ 2x optional 3.25 µm @ 4x 1.3 µm @ 10x 0.65 µm @ 20x 0.33 µm @ 40x	6.5 µm @ 2x optional 3.25 µm @ 4x 1.3 µm @ 10x 0.65 µm @ 20x 0.33 µm @ 40x optional	0.086x magnification
Automated whole well/whole plate imaging	✓	✓	✓	✓	whole plate one shot
Sample types	SBS plate format (6-384 wells), culture dishes and microscope slides	SBS plate format (6-384 wells), culture dishes and microscope slides	SBS plate format (6-384 wells), culture dishes and microscope slides	SBS plate format (6-384 wells), culture dishes and microscope slides	myrPlates
Camera	8 bit progressive scan CMOS	8 bit progressive scan CMOS	16 bit sCMOS	16 bit sCMOS	8 bit progressive scan CMOS
Pixel density	5440x 5440 29.6 MPx	4496 x 4496 20.2 MPx	2048 x 2048 4.19 MPx	2048 x 2048 4.19 MPx	3088 x 2064 6.4 MPx
Quantum efficiency (relevant to detect weak fluorescence)	~57 %	~66 %	> 80 %	~80 %	80 %
Light source	High performance long-life LED	High performance long-life LED	High performance long-life LED	High performance long-life LED	Long-life LED
Illumination / Fluorescence¹	Brightfield and 6 fluorescence excitation/emission channels	Brightfield and 4 fluorescence excitation sources, up to 5 fluorescence emission filters	Brightfield and 6 fluorescence excitation/emission channels	Brightfield and 4 fluorescence excitation sources, up to 5 fluorescence emission filters	Long-life LED
Temp.-control	Possible³	×	Possible³	×	24/7 incubator integration
Image acquisition- & device controlling software⁴	YT-SOFTWARE®⁴	YT-SOFTWARE®⁴	YT-SOFTWARE®⁴	YT-SOFTWARE®⁴	YT-myrImage
Automation-ready set up	✓	✓	✓	×	N.A.
Software-interface for automation	✓	✓	✓	✓	N.A.
Batch processing interface	✓	✓	✓	✓	N.A.
External barcode-reader	Optional	Optional	Optional	Optional	Optional

¹ Different system configurations like e.g. basic systems with brightfield only or customized filter and objective lenses set-ups are available.
² Throughput per day depends on experiment configurations (e.g. exposure time, plate type, focus options, # of imaging channels…).
³ CELLAVISTA® can be equipped with the ibidi® heating and incubation system (other systems not tested). Due to pH-shift and consequent cell stress a heating option only is not recommended.
⁴ YT-SOFTWARE® includes the same image analysis tools for both CELLAVISTA® and NYONE®. Differences in usable applications arise only due to different hardware configurations (e.g. different illuminations or camera chips).
⁵ Hardware automation-package available.

DO YOU WANT TO KNOW MORE?

We know that time is an increasingly scarce resource, even in the lab. That's why we've thought your problem through and have everything ready for a complete one-handed solution.

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