Example assay setup for automation

Hardware

IMAGING SYSTEMS AND AUTOMATION SOLUTIONS

By developing and providing fluorescence and brightfield imaging systems and applications, SYNENTEC introduces the most versatile cell imaging systems on the market and also offers proprietary automation solutions such as plate handlers and automated assay incubators, as well as ready-to-use assay kits. Leading the way are the various software- and image analysis packages, which can be expanded according to customer needs.

Choose your weapon

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CELLAVISTA Scientific & 4K

Ultrahigh-throughput imaging system that non-invasively measures brightfield and fluorescence assays in multi-well plates, chamber slides or RoboFlasks for an extremely broad range of cellular applications in CLD, cellular research and drug discovery.

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NYONE Scientific & 4K

This fully automated cell imager is characterized by its mechanical robustness, optical quality and functionality balanced features in a way that you will soon recognize that NYONE® is a reliable member of your team. 

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SYBOT X-1000 & CYTOMAT

SYNENTEC offers various peripheral products and robotics for automation to extend functionality and to improve laboratory processes as well as increase throughput and walk away time.

RESOLUTION MATTERS

Get an idea of the 4k resolution

Explore HCS image analysis capabilities

High content screening using 4K resolution

High content screening using 4K resolution. This image of A549 cells beautifully demonstrates the capabilities of SYNENTEC's CELLAVISTA 4K imager. The actin filaments can be recognized with impressive high definition.

This image of A549 cells impressively demonstrates the capabilities of SYNENTEC's CELLAVISTA 4K imager. The actin filaments can be recognized with impressive high definition.

 

COMPARE TECHNICAL SPECIFICATIONS

 

CELLAVISTA® 4K HighEnd1

NYONE® 4K HighEnd1

CELLAVISTA® 4 Scientific

NYONE® Scientific

Throughput

250² plates / day

100² plates / day

250² plates / day

150² plates / day

Objective capacity

4

3

4

3

Selectable Resolutions1

3.3 µm @ 2x optional
1.3 µm @ 4x
0.9 µm @ 10x
0.53 µm @ 20x
0.35 µm @ 40x

1.3 µm @ 4x
0.9 µm @ 10x
0.53 µm @ 20x

6.5 µm @ 2x optional
3.25 µm @ 4x
1.3 µm @ 10x
0.65 µm @ 20x
0.33 µm @ 40x

6.5 µm @ 2x optional
3.25 µm @ 4x
1.3 µm @ 10x
0.65 µm @ 20x
0.33 µm @ 40x optional

Automated whole well/whole plate imaging

Sample types

SBS plate format (6-384 wells), culture dishes and microscope slides

SBS plate format (6-384 wells), culture dishes and microscope slides

SBS plate format (6-384 wells), culture dishes and microscope slides

SBS plate format (6-384 wells), culture dishes and microscope slides

Camera

8 bit progressive scan
CMOS

8 bit progressive scan
CMOS

16 bit sCMOS

16 bit sCMOS

Pixel density

5440x 5440
29.6 MPx

4496 x 4496
20.2 MPx

2048 x 2048
4.19 MPx

2048 x 2048
4.19 MPx

Quantum efficiency
(relevant to detect weak fluorescence)

~57 %

~66 %

> 80 %

~80 %

Light source

High performance long-life LED

High performance long-life LED

High performance long-life LED

High performance long-life LED

Illumination / Fluorescence1

Brightfield and 6 fluorescence excitation/emission channels

Brightfield and 4 fluorescence excitation sources, up to 5 fluorescence emission filters

Brightfield and 6 fluorescence excitation/emission channels

Brightfield and 4 fluorescence excitation sources, up to 5 fluorescence emission filters

Temp.-control

Possible3

×

Possible3

×

Image acquisition- & device controlling software4

YT-SOFTWARE®4

YT-SOFTWARE®4

YT-SOFTWARE®4

YT-SOFTWARE®4

Automation-ready set up

×

Software-interface for automation

Batch processing interface

External barcode-reader

Optional

Optional

Optional

Optional

1 Different system configurations like e.g. basic systems with brightfield only or customized filter and objective lenses set-ups are available.
2 Throughput per day depends on experiment configurations (e.g. exposure time, plate type, focus options, # of imaging channels…).
3 CELLAVISTA® can be equipped with the ibidi® heating and incubation system (other systems not tested). Due to pH-shift and consequent cell stress a heating option only is not recommended.
4 YT-SOFTWARE® includes the same image analysis tools for both CELLAVISTA® and NYONE®. Differences in usable applications arise only due to different hardware configurations (e.g. different illuminations or camera chips).
5 Hardware automation-package available.

Discover all advantages

HIGH CONTENT IMAGING & AUTOMATION

Automation Solutions

Example assay setup

Example assay setup for automation

We offer innovative methods and technologies to help you achieve your R&D goals. Our automated cell imagers provide the highest image quality of any cell imaging system on the market, and combined with cutting edge software suites and laboratory automation solutions, ensure the most effective support in your field of application. Some typical examples:

  • Cell Line Development (e.g. Single Cell Cloning, Proof of Monoclonality, CRISPR/Cas9 Tracking, Transfection Efficiency, Cell Viability Monitoring, PAIA Protein Titer Measurements, PAIA Glycosylation Measurements, Fluorescent Activated Single Cell Cloning (FASCC)) 
  • Cancer Research and Drug Discovery (e.g. Imaging of 3D Spheroids, Toxicity Testing, IC50 studies, Cell Expansion Tracking, Apoptosis Monitoring, Nucleus Characterization, Wound Healing & Migration Assay, yH2AX-DNA-Damage, Cell Cycle & Mitosis)
  • Stem Cell Research (e.g. iPS Colony Count, Fluorescent Pluripotency Studies, Validation of Proliferation and Cell Migration, Cell Differentiation Analysis, Recombinant Lectin Probes, Cornea Cell Count, siRNA Detection, iPS-Cell-Marker Characterization)
  • Immunology (e.g B-Cell and T-Cell Studies, Cytotoxic T-Lymphocyte Testing, Evaluation of Helper T-Cells and Subsets, Performing Cell Death Studies)
  • Vaccine Research (e.g. Focus Forming Assay (FFA) for Virus Titer Quantification, Immunofluorescence Foci Assay (IFA) for Viral Infectivity, Viral Plaque Assay, Viral Pathogenesis with Quantifying Morphological Changes, Transduction Efficiency with Fluorescence Coupled Gene Expression, Cytopathic Effect Quantification (Viral CPE))