The broadest range of cell culture applications supported by flexible, automated high-throughput imaging systems and user-friendly analysis software.

Cell Line Development

FASCC_Ghost Cell_Well Edge_Calcein Fluo and detection FASCC_Ghost Cell_Well Edge_Brightfield only

The development of a new cell line with the characteristics of interest is a highly complex process consisting of many successive steps, mainly leading into the goal to produce specific biopharmaceuticals. 

Herein single cell cloning (SCC) represents a critical stage. The aim of SCC is to identify and isolate the most productive monoclonal cell populations after transfection or hybridization. Our Systems greatly provide the determination of monoclonality in different customizable approaches - here, fluorescence-assisted single cell cloning (FASCC) is to be particularly highlighted.

Furthermore controlling your transfection efficiency, determining the cell number, cell viability and the apoptosis rate e.g. in fed-batch cultures, detecting and counting colonies and quantifying IgG levels can be carried out reliably with SYNENTEC's imaging systems.

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Vaccine Research

Viral Transduction_FFA_BF only Viral Transduction_FFA_Fluo and Colony Detection

SYNENTEC's profound experience in the field of virus research and vaccine development enables us to provide a wide range of applications in this area for our customers worldwide.

The high-throughput imaging systems CELLAVISTA® and NYONE® accelerate your work in various areas of virological research. Our automated cell imagers support your research with high-resolution imaging in brightfield and diverse fluorescence channels in combination with automated YT-software® for image cytometry.

We support the vaccine research & development (Influenca, Noro, SARS-CoV-2, Malaria, HIV...) for human and veterenary vaccines as well as the CLD upstream processes for production purpose (therefore please refer to CLD-section).

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Stem Cells

High-content imaging using induced pluripotent stem cells (hiPSCs) of human origin can be applied to examine neurotrophic, neuroprotective, or neurotoxic effects of pharmaceutical drug candidates or environmental contaminants. High-content imaging using induced pluripotent stem cells (hiPSCs) of human origin can be applied to examine neurotrophic, neuroprotective, or neurotoxic effects of pharmaceutical drug candidates or environmental contaminants.

Neuronal and glial differentiation.

Characterization of pluripotency is an important aspect of stem cell research. Pluripotency refers to the potential of cells to differentiate it into any of the three germ layers. This property is shared by embryonic stem (ES) cells, embryonic germ (EG) cells and embryonic carcinoma (EC) cells.

Due to the rare availability, the ethical concerns and difficult cultivation, the investigation of induced pluripotent stem (iPS) cells is moving more and more into the focus of stem cell research. Like ES cells iPS cells are also pluripotent without having the disadvantages of ES cells.

Fluorescent labeled antibodies or colorimetric detection of pluripotency markers are provided with the brilliant optical resolution of SYNENTEC's imaging systems as well as validation of the proliferation and cell migration for wound healing assays.

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Drug Discovery and Cancer Research

3D-Spheroid in Brightfield 3D-Spheroid with LIVE/DEAD staining

The search for novel therapies against cancer is one of the most important areas of modern health research. But the diagnosis, prevention and aftercare must also be investigated. Having a fast and reliable way to perform in vitro pre-selections of individual compound collections is an important step which massively speeds up the entire process of drug discovery.

Especially in the sector of developing new diagnostic tools and also to understand the way of knock out mechanisms, CD-marker (cluster of differentiation) play an important role. But also, the study of the complexity of cancer in the widely used two-dimensional (2D) single-layer cell culture systems is being replaced by the three-dimensional (3D) cell culture models, well reasoned.

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Immuno histo chemistry of a colon slice. Here brightfield only. Immuno histo chemistry of a colon slice. Fluorescence overlay without image analysis.

In the R&D-area of cellular immunology, many subcategories can be divided – e.g. infectiology, study of immune deficiencies, the vaccine development, development of therapeutic antibodies and the reproductive immunology.

All areas combines that complex cell assays have to be performed on mostly rare samples with expensive consumables. To ensure the accuracy and reproducibility of experiments and to save the samples, a fast and automated measurement and image analysis method should be selected.

The standardized use of SYNENTEC’s automated cell imagers CELLAVISTA® and NYONE® in combination with the YT-image processing software® helps to satisfy this high standard.

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